|Author: ||H. Saito|
We investigated the effects of saffron extract and its ingredients on learning behaviors and long-term potentiation (LTP). Oral administration of Crocus sativus L. extract (CSE) antagonized both ethanol-induced memory impairment and ethanol-induced suppression of LTP generation.
Crocin was the main active component in the CSE, with regards to both learning performance and LTP generation, and its pharmacological action was triggered via modulation of the central NMDA receptors.
The results suggested that crocin improved learning deficits by attenuating the inhibitory effect of ethanol on LTP generation, and highlighted the possibility that crocin is a candidate for an ethanol-induced central nervous system disorders’ therapeutic.
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