ISHS Acta Horticulturae 744: I International Symposium on Human Health Effects of Fruits and Vegetables
EXTRACTS FROM ORGANICALLY AND CONVENTIONALLY CULTIVATED STRAWBERRIES INHIBIT CANCER CELL PROLIFERATION IN VITRO |
| Authors: | M.E. Olsson, S.C. Andersson, R.H. Berglund, K.-E. Gustavsson, S. Oredsson |
| Keywords: | Fragaria × ananassa, antioxidant, ascorbate, vitamin C, anthocyanidin, phenolics, flavonol |
| Abstract:
The effects of extracts from strawberries of cv. ‘Honeoye’, grown in both organic and conventional production systems, on cancer cell proliferation in vitro were investigated. The content of several antioxidants in the strawberry extracts were analysed and compared with the inhibition effect on cancer cell proliferation. The strawberry extracts inhibited cell proliferation in colon cancer cells HT29 and breast cancer cells MCF-7 in a concentration dependent way. Extracts from organically grown strawberries inhibited cell proliferation to a higher extent than conventionally grown at the two highest concentrations. This might indicate that the content of secondary metabolites with anticancer properties were higher in the organically grown strawberries. There were great differences in the content of the analysed antioxidants between the two cultivation methods. The content of ascorbate was 36% higher and the ratio of ascorbate to dehydroascorbate were eight-fold higher in the organically grown strawberries than in the conventionally grown, whereas the content of ellagic acid, total anthocyanidins and total phenolics were lower. No significant differences were found in the content of hydroxycinnamic acid and flavonols between the two production systems. The higher content of ascorbate found in the organically grown strawberries might have affected the higher inhibition of cancer cell proliferation by the extracts from the organically produced strawberries compared to the conventionally grown strawberries. Ascorbate is suggested to act synergistically with other substances in the extracts. | |
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