ISHS Acta Horticulturae 709: I International Symposium on Natural Preservatives in Food Systems
NATURAL PRODUCT SCREENING FOR ANTIBACTERIAL AGENTS |
| Author: | L.L. Silver |
| Keywords: | antibacterial, antibiotic, natural products, screening |
| Abstract:
Screening of natural products for antibacterial activity has a long history, but the output of useful new chemical entities has decelerated. Natural products programs have been largely abandoned by large pharmaceutical companies as an antibacterial screening source in the age of high throughput target-directed screening of chemical libraries and the search for new leads for chemical optimization. However, this approach has not been very productive and natural products may once again provide an attractive source of novel antibacterial compounds. Application of modern technology to increase sample sources, assay throughput, speedier chemical isolation, and, most importantly, dereplication (rapid identification of common compounds) by biological and chemical means, can aid in further exploitation of the rich natural product universe. However, the lessons of the past should not be forgotten and this brief review offers some context for this renewed attack. | |
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