ISHS Acta Horticulturae 680: III WOCMAP Congress on Medicinal and Aromatic Plants - Volume 6: Traditional Medicine and Nutraceuticals
PREVENTIVE EFFECTS OF GARLIC EXTRACT ON LIPID PEROXIDATION AND ANTIOXIDANT DEFENCE SYSTEM IN N-NITROSODIETHYLAMINE INDUCED HEPATOCARCINOGENESIS IN RATS |
| Authors: | S. Sundaresan, P. Subramanian |
| Keywords: | chemoprevention, enzymatic antioxidants, hepatocellular carcinoma, organosulphur compounds, vitamin C, vitamin E |
| Abstract:
Effects of garlic (Allium sativum) on circulatory lipid peroxidation and antioxidant status were evaluated in N-Nitrosodiethylamine induced hepatocarcino-genesis in male rats. Enhanced lipid peroxidation in the circulation of N-Nitrosodiethylamine (NDEA) treated rats was accompanied by a decrease in the levels of vitamins C and E, reduced glutathione, glutathione peroxidase, superoxide dismutase and catalase. Garlic administered rats experienced a significant reduction in lipid peroxidation with a simultaneous elevation in antioxidant levels. The presence of organosulphur compounds in garlic could have decreased lipid peroxidation and increased antioxidants levels in NDEA administered rats. | |
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