|Authors: ||N. Pongphasuk, W. Khunkitti, M. Chitcharoenthum|
|Keywords: ||acute toxicity, Clinacanthus nutans, Cyperus rotundus, Nyctanthes arbortristis, sub-chronic toxicity, Thunbergia laurifolia|
The anti-inflammatory activity of extracts from Garcinia mangostana Linn., Nyctanthes arbortristis Linn., Cyperus rotundus L. and Clinacanthus nutans (Burm.f.) Lindau were tested in mice using carrageenan induced paw edema.
All extracts (5 g/kg, p.o.) had anti-inflammatory activity at 3 h (P>0.01) and 6 h (P>0.001). Among all the extracts studied, the extract of G. mangostana showed the highest anti-inflammatory activity with 45% inhibition at these two time points.
The result of dose response study (1.0, 2.0, 4.0 g/kg, p.o.) showed dose-dependent activity.
Analgesic activity was also tested using heated glass.
None of the extracts had marked analgesic activity.
Sub-chronic toxicity study of G. mangostana extract showed low safety (TI 2, LD50= 9.37 g/kg). Mice fed this extract at 1, 2, 4, 8 g/kg/d, showed death rates of 0, 15, 17, 43% respectively during 30 d. T. laurifolia extract had anti-inflammation efficacy 2-folds greater than G. mangostana extract (ED50 T. laurifolia = 2.51 g/kg, ED50 G. mangostana = 5.51 g/kg). In the toxicity study of T. laurifolia extract in mice at 1, 2, 4, 8 g/kg/d, no mice died during 30 d. T. laurifolia extract was the most effective and safe.
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