ISHS Acta Horticulturae 675: III WOCMAP Congress on Medicinal and Aromatic Plants - Volume 1: Bioprospecting and Ethnopharmacology
DEPRESSANT EFFECT OF TRIMYRISTIN AND ITS INHIBITION BY SOME ANTIDEPRESSANTS IN MICE |
| Authors: | S.B. Kasture, K.N. Gujar |
| Keywords: | amitriptyline, fluoxetine saprogrelate, imipramine, mianserin |
| Abstract:
The depressant activity of trimyristin and its interaction with antidepressants like amitryptiline, imipramine, mianserin, and fluoxetine has been studied. In forced swim tests and tail suspension tests male albino mice were treated intraperitoneally with 10 mg/kg each of amitryptiline, imipramine, mianserin, and fluoxetine 30 min before vehicle or trimyristin (10 or 30 mg/kg i.p.). Some groups received trimyristin (10 or 30 mg/kg i.p.). In reserpine-induced hypothermia, the effect of trimyristin was observed on hypothermia induced by reserpine. In forced swim tests and tail suspension test, trimyristin increased the duration of immobility and pretreatment with antidepressants inhibited the effect of trimyristin. Trimyristin significantly lowered the rectal temperature and potentiated the reserpine-induced hypothermia. In the forced swim tests, the depressant effect of trimyristin was inhibited by prior administration of serotonin 5-HT2A receptor antagonist, saprogrelate suggesting involvement of serotonergic and noradrenergic mechanisms in the depressant action of trimyristin. | |
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