ISHS Acta Horticulturae 675: III WOCMAP Congress on Medicinal and Aromatic Plants - Volume 1: Bioprospecting and Ethnopharmacology
PHYTOCHEMICAL AND ANTIMALARIAL STUDIES ON SWERTIA ALATA ROYLE |
| Authors: | M. Karan, S. Bhatnagar, P. Wangtak, K. Vasisht |
| Keywords: | in vivo test, in vitro test, plant extracts, xanthones |
| Abstract:
Different species of genus Swertia are used in different countries for a variety of ailments including malaria. More than 85 xanthones and 17 secoiridoid bitters have been isolated from different species of Swertia. In the present study, the whole plant of Swertia alata Royle was investigated and three xanthones 1,8-dihydroxy-3,7-dimethoxyxanthone, 1,7,8-trihydroxy-3-methoxyxanthone and 1-hydroxy-3,7,8-trimethoxyxanthone were isolated from different extracts. The total methanolic extract, its hexane soluble portion, chloroform soluble portion of petroleum ether extract and three isolated xanthones were tested in vitro at different dose levels for antimalarial activity. The activity was expressed as percent invasion inhibition of the tested parasite. The results indicated that all extracts and xanthones possessed some protective effect, however only 1,8-dihydroxy-3,7-dimethoxyxanthone exhibited significant activity and was therefore, further tested in vivo in Plasmodium berghei test model. 1,8-dihydroxy-3,7-dimethoxyxanthone produced the most significant reduction in percent parasitaemia at 10 mg/kg dose level. | |
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