ISHS Acta Horticulturae 675: III WOCMAP Congress on Medicinal and Aromatic Plants - Volume 1: Bioprospecting and Ethnopharmacology
INVOLVEMENT OF GABA IN NOOTROPIC AND ANXIOLYTIC ACTIVITY OF SAPONINS OF ALBIZZIA LEBBECK LEAVES |
| Authors: | K.N. Gujar, S.B. Kasture |
| Keywords: | anxiety, baclofen, behavior, n-butenolic fraction (BF) |
| Abstract:
The effect of saponin containing n-butanolic fraction (BF) extracted from dried leaves of Albizzia lebbeck was studied on cognitive behavior and anxiety in albino mice. An elevated plus maze was used for assessment of both nootropic and anxiolytic activity. The nootropic activity was assessed by recording the effect of BF (10-50 mg/kg) on the transfer latency, anxiolytic activity was evaluated by measuring the effect on duration of occupancy in the open arm. The studies showed that BF possesses anxiolytic activity and nootropic activity. BF inhibited baclofen-induced hypothermia and passivity. Thus the study suggests that saponins act by modifying GABA ergic mechanism. | |
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