ISHS Acta Horticulturae 675: III WOCMAP Congress on Medicinal and Aromatic Plants - Volume 1: Bioprospecting and Ethnopharmacology
CHEMICAL AND PHARMACOLOGICAL SURVEY ON BRAZILIAN MEDICINAL PLANTS USING ETHNOPHARMACOLOGICAL INFORMATION AS A TOOL |
| Authors: | F.S. Menezes, D.Q. Falcão, R.F.W. de Mendoça Filho, C.S. Silveira, M.N. Rennó, V.P. Rodrigues, A.B.M. Minto, D.L. Moreira, M.E. Matheus, P.D. Fernandes, M.A.C. Kaplan |
| Abstract:
The project encompasses plants from the following families: Palmae, Lamiaceae, Acanthaceae, Leguminosae and Gesneriaceae. Regarding the pharmacology, several models have been used like antinociceptive, anti-inflammatory, antioxidant, molluscicidal, anti-diabetes, anti-microbial and nitric oxide production inhibition. Results showed that utilizing ethnopharmacological information is a very important way to search for new bioactive molecules. It is noteworthy to mention the activity of Açaí fruit extracts in the inhibition of nitric oxide production. It was also possible to identify flavonoids responsible for the antidiabetic activity in plants belonging to the family Leguminosae. Acanthaceae extracts showed important antinociceptive and anti-inflammatory activities, as they are very rich in steroids and triterpenes. The same could be said about plants belonging to Lamiaceae that gave several examples of this kind of pharmacological property due to its steroid and triterpenoid compounds. One specie of Lamiaceae also produced a great amount of dihydroxylated triterpenoids with great molluscicidal potencial. Palmae species, rich in fatty acids and steroids led to enriched extracts responsible for the anti-BPH activities. Plants belonging to Gesneriaceae were antioxidant due to their flavonoid content. Polar extracts and isolated molecules, isolated from many species were able to donate hydrogen radical to DPPH. | |
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