ISHS Acta Horticulturae 650: I International Symposium on Saffron Biology and Biotechnology
ADDITIVE INHIBITORY EFFECT OF SAFFRON IN COMBINATION WITH SODIUM SELENITE ON TUMOR CELLS |
| Authors: | L. Riverón-Negrete, R. Camacho-Carranza, H. Caballero-Ortega, J.M. Hernández, M. Medécigo-Ríos, A. Castillo-Villanueva, I. Pérez-López, J.J. Espinosa-Aguirre, F. Abdullaev |
| Keywords: | chemoprevention, Crocus sativus L., cytotoxicity, DNA and RNA synthesis |
| Abstract:
Both saffron and selenium have been reported to exhibit antigenotoxic and cancer chemopreventive activities. We have examined the effects of naturally occurring saffron extracts in combination with sodium selenite on colony formation and nucleic acid synthesis of different human cultured malignant cells. Results of these experiments demonstrated that saffron in combination with sodium selenite displays an additive inhibitory effect on colony formation and nucleic acid synthesis in tumor cells at low concentrations of both agents. These results suggest the potential use of saffron as an anticancer agent, alone or in combination with sodium selenite. | |
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