ISHS Acta Horticulturae 467: III International Symposium Diversification of Vegetable Crops
CANCER PREVENTIVE POTENTIALS OF VEGETABLES AND FRUITS FROM SOUTHEAST ASIA AND SOME OF THEIR ACTIVE CONSTITUENTS |
| Authors: | K. Koshimizu, A. Murakami, H. Ohigashi |
| Keywords: | cancer prevention, Citrus hystrix, bitter orange, Languas galanga, great galangal, glyceroglycolipid, acetoxychavicol acetate |
| Abstract:
A total of 112 species of edible plants (122 samples) from Thailand were randomly collected, and their methanol-extracts screened for in vitro anti-tumor promoting activity using the inhibition test of tumor promoter-induced Epstein-Barr virus (EBV) activation in Raji cells. It was found that 60% of these extracts inhibited EBV activation by 30% or more at a concentration of 200 mg/ml. It should be noted that the ratio was markedly higher than that (26%) previously observed in common edible plants in Japan. The species in the families Labiatae, Piperaceae, Rutaceae and Zingiberaceae were promising sources of effective anti-tumor promoters. In addition, anti-tumor promoting effects of two active constituents, 1,2-di-O-  -linolenoyl-3-O- -galactopyranosyl-sn-glycerol (DLGG, Citrus hystrix), and 1'-acetoxychavicol acetate (ACA, Languas galanga), together with their possible mode of action investigated thus far, are described.
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