ISHS Acta Horticulturae 426: International Symposium on Medicinal and Aromatic Plants
PHARMACOGNOSTICAL STUDIES ON THE ROOTS OF PIPER NIGRUM L. II: CHEMICAL AND PHARMACOLOGICAL STUDIES |
| Authors: | S. Hu, P. Ao, H. Tan |
| Keywords: | Pepper root, Piper nigrum L., amide alkaloids, phytochemistry, bioactivities |
| Abstract:
Three amide alkaloids of Piper nigrum L. such as piperine, pellitorine, 3,4-dimethyinenedioxycinnamoyl-piperidine, and ß-sitesterol were isolated from the ethanol extract, purified and identified. Pharmalogical experiments showed that the ethanol extract had anticonvulusive, sedative, and analgesic activities to mice at the dosage level 2 g/kg orally. LD50 of the ethanol and the water extracts to mice were respectively 12.66 and 424.38 g/kg converted into crude material. | |
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