ISHS Acta Horticulturae 306: International Symposium on Medicinal and Aromatic Plants, XXIII IHC
BIOSYNTHESIS OF THE ANTINEOPLASTIC PANCRATISTATIN FOLLOWING TISSUE CULTURE OF HYMENOCALLIS LITTORALIS (AMARYLLIDACEAE) |
| Authors: | R.A. Backhaus, G.R. Pettit III, D.-S. Huang, G.R. Pettit, G. Groszek, J.C. Odgers, J. Ho, A. Meerow |
| Abstract:
A method for the large scale production of Hymenocallis littoralis (Pancratium littorale) by tissue culture is described. This species serves as an effective source of pancratistatin, a powerful anticancer agent, as well as an attractive landscape ornamental. Chemical analysis of field- and greenhouse-grown, tissue-culture derived plants revealed that pancratistatin is produced primarily in bulbs and, to a lesser degree, in roots, but not in leaves or seeds of this species. Bulbs cultivated in Arizona produced ca. 9–24 mg/kg f.w. pancratistatin compared with earlier reports of 144 mg/kg from bulbs grown in Hawaii (Pettit et al., 1984b). The reason for this difference is unknown. | |
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