Abstract:
The antracene-derivatives containing drugs Aloe, Rhei rhizoma, Sennae folium et fructus, and Frangulae cortex official laxativa in Pharmacopoeia Hungarica VI. (Ph.
Hg.
VI.) constitute components of several galenica, and other pharmaceutical preparates.
Since, like in most European countries, also Hungary imports great quantities of these drugs (with the exception of the last one) it has seemed relevant to look for new drugs of nearly the same therapeutic value, that can be cultivated in Hungary and so could substitute the drugs mentioned above.
In the course of preliminary experiments, it could be established that Rumex alpinus L. (Polygonaceae) can be cultivated with success under the climatic conditions of Hungary.
In sandy soil, the crude-drug yield of underground plant parts amounted to nearly 30 t/ha (in the third year of cultivation), while the content of active principles reached 2.5%, with two maxima in spring and autumn.
The spring maximum is approx. 30% higher.
The drugs of underground plant parts almost entirely meet the requirements of Ph.
Hg.
VI. concerning other anthracene-derivative containing drugs (Frangulae cortex, Rhei rhizoma).
The relatively high crude yield of leaves reached 34 t/ha in the third year of cultivation, while their net protein content varied between 20. 6–28. 6% in the course of the vegetation period, which are relatively high values.
Analysing by TLC method it could be established that concerning their anthracene-derivative content the drugs Rumicis alpini rhizoma et radix have proved to be similar to the laxativa Rhei rhizoma and Frangulae cortex, as well as the dermatologicum Chrysarobin.
In harmony with data in the special literature it has been established that the drugs Rumicis alpini rhizoma et radix seem
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